In the franchise, Desmond is a descendant of a long line of important characters, including Adam, Aquilus, Altaïr Ibn-La'Ahad, Ezio Auditore da Firenze, Edward Kenway, Haytham Kenway, and Ratonhnhaké:ton / Connor, most of whom were members of the Assassin Brotherhood, a fictional organization inspired by the real-life Order of Assassins that is dedicated to safeguarding peace and freedom. According to several video game journalists and authors, Desmond's character is meant to represent a form of transcendence symbolically from the necessity of the human body. He is voiced by actor Nolan North, and is modeled after Canadian fashion model Francisco Randez.

Desmond has also been referenced or featured in a smaller capacity in subsequent games in the series, as well as various spin-off media.

Introduced as the protagonist of the modern-day sections of the first Assassin's Creed game, he maintained this role for the next four installments, with his journey and development making up the frame story that unites the first five Assassin's Creed titles. Desmond Miles in Assassin's Creed: Brotherhoodĭesmond Miles is a fictional character from Ubisoft's Assassin's Creed video game franchise.

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